Introduction

Late February of 2012 Mark was diagnosed with stage 4 Metastatic Melanoma Cancer. This is written for our family and friends who have so caringly expressed a desire to know of the current situation. We so appreciate the love and support that has been shown to us and we lovingly empathize with and pray for many of you that have had or are currently going through trials of your own. In love, hope and faith, Mark and Ane

Monday, March 13, 2017

Fourth Infusion and Feeling Fine!

Today Mark had his fourth infusion.  We got there around 1 pm and left at 5:30 pm - it seemed a bit slower than usual.  In three weeks he will have the last infusion of Ketruda combined with the clinical trial drug Galectin.  From then on our visits will take much less time with just 30 minutes of Ketruda along with blood draws, a doctor visit and waiting for the results of the lab work before the infusion can begin.  The Galectin took an hour, plus an hour wait before starting the Ketruda.  

Chris who supervises the clinical trial told us today that there are currently 6 patients on this regiment at Providence Portland.  One man who has been on it for over a year, has almost total shrinkage of tumors.  The other four have unfortunately not had a positive response.  How sad and disappointing!  Mark is doing amazingly well!!  Not only are tumors shrinking, but the side effects have been minimal.  He just started having some skin rashes which are fairly common and can be treated with good creams. Fatigue is the most common side effect and he seems to keep increasing in his energy level as the tumors shrink.  

Mark found a report of the clinical trial of Ketruda (pembrolizumab) completed just a year ago.  The results are definitely the best yet for metastatic melanoma, but reading through it doesn't sound all that promising. Today we felt the reality of how blessed we are when we realized that only two of six in this new clinical have had positive progression, and he is one of them!

Study Details

KEYNOTE, a phase Ib trial, enrolled 655 patients treated. Patients were treated with pembrolizumab until disease progression, intolerable toxicity, or investigator decision.

At a median follow-up of 32 months, 358 patients (55%) had died. At 36 months, the overall survival rate was 40%.

A total of 95 patients (15%) achieved a complete response. Among them, 61 (64%) stopped treatment after complete response. Only 2 of the 61 patients who stopped treatment after complete response experienced disease progression. One of the two has been restarted on therapy, but it is too early to evaluate response, Dr. Robert said.


The most common treatment-related adverse events were fatigue (40%), pruritus (28%), and rash (23%). Only 8% of patients stopped pembrolizumab because of side effects.


3 comments:

  1. Libbie StephensonMarch 14, 2017 at 6:23 PM

    Hello Mark,
    I don't know if you remember me from San Bernardino days and Del Vallejo junior high. I thought of you because I saw that someone named Alex Hornibrook will be the QB for Wisconsin Badgers. I remember attending a party at your house with Howard Cowlishaw and others. And then I saw your blog post. I wanted to wish you all the best in your treatment and recovery. It is amazing what science and medicine can do these days. It sounds like you have found a treatment that is working and that you have a terrific support group. I will keep you in my thoughts and prayers. If my name rings a bell and you would like to catch up, my email address is libbie@g.ucla.edu. But no pressure. Wishing you all the best in your recovery. Libbie Stephenson

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  2. Mark - Glad to see your energy levels rising. Great to catch up. Just keep moving forward. Best to Ane from Lynn and me. Brian

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  3. Mark and Ane, I check this blog almost daily to see what the latest is, so very thankful for another great report. My very first thought as I read this was "Praise God from who all Blessings flow...we look forward to seeing you soon.

    Rick and Cheryl

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